Geriatric patients often have altered pharmacokinetics and pharmacodynamics due to factors such as impaired renal and hepatic function, reduced body water, and increased body fat. These changes increase the likelihood of adverse drug reactions and toxicity, requiring careful dose adjustments. Reduced renal function can lead to the accumulation of medications that are renally excreted, increasing the risk of toxicity. Monitoring renal function and adjusting medication dosages accordingly is crucial.
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